Article

A twin UGUA motif directs the balance between gene isoforms through CFIm and the mTORC1 signaling pathway

2022-08-31

Abstract excerpt

<h4>SUMMARY</h4> Alternative polyadenylation (APA) generates mRNA isoforms and diversifies gene expression. Here we report the identification of a twin UGUA motif, UGUAYUGUA, and its function in APA. Applying cTag-PAPERCLIP to Tsc1 conditional knockout mice, we discovered that the mTORC1 pathway balances expression of Trim9 isoforms. We showed that CFIm components, CPSF6 and NUDT21, promote Trim9/TRIM9-S expre...

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Literature Corpus work: 291a7d46-130d-5b3c-a29f-77798942aad2
DOI: 10.1101/2022.08.31.506015

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