Article

Inhibition of ATR Reverses a Mitochondrial Respiratory Insufficiency

2019-10-16

Abstract excerpt

<h4>ABSTRACT</h4> Diseases that affect the mitochondrial electron transport chain (ETC) often manifest as threshold effect disorders, meaning patients only become symptomatic once a certain level of ETC dysfunction is reached. Multiple processes work to control proximity to the critical ETC threshold and as a consequence there can be significant variability in disease presentation among patients. Identification o...

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Literature Corpus work: 52bd0dab-f3f3-5982-a1a6-2570e3e714d1
DOI: 10.1101/805390

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