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Misregulation of mitochondrial 6mA promotes the propagation of mutant mtDNA and causes aging in C. elegans.

Cell metabolism - 3 Dec 2024

Hahn Anne, Hung Grace Ching Ching, Ahier Arnaud, Dai Chuan-Yang, Kirmes Ina, Forde Brian M, Campbell Daniel, Lee Rachel Shin Yie, Sucic Josiah, Onraet Tessa, Zuryn Steven

Abstract excerpt

In virtually all eukaryotes, the mitochondrial DNA (mtDNA) encodes proteins necessary for oxidative phosphorylation (OXPHOS) and RNAs required for their synthesis. The mechanisms of regulation of mtDNA copy number and expression are not completely understood but crucially ensure the correct stoichiometric assembly of OXPHOS complexes from nuclear- and mtDNA-encoded subunits. Here, we detect adenosine...

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PMID: 39173633
DOI: 10.1016/j.cmet.2024.07.020

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