Article

Preserving protein homeostasis prevents motor impairment in DNA Damage Response-compromised <i>C. elegans</i>

2021-12-22

Abstract excerpt

<h4>ABSTRACT</h4> To maintain genome integrity, cells rely on a complex system of DNA repair pathways and cell cycle checkpoints, together referred to as the DNA damage response (DDR). Impairments in DDR pathways are linked to cancer, but also to a wide range of degenerative processes, frequently including progressive neuropathy and accelerated aging. How defects in mechanistically distinct DDR pathways can drive...

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Literature Corpus work: 8457c407-3d92-52ba-9c9a-8ac389a69a96
DOI: 10.1101/2021.12.22.473820

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