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Article

Early-life mitochondrial DNA damage results in lifelong deficits in energy production mediated by redox signaling in <i>Caenorhabditis elegans</i>

2020-11-26

Abstract excerpt

The consequences of damage to the mitochondrial genome (mtDNA) are poorly understood, although mtDNA is more susceptible to damage than nuclear DNA (nucDNA), and many environmental toxicants target the mitochondria. Reports from the toxicological literature suggest that exposure to early-life mitochondrial damage could lead to deleterious consequences later in life (the “Developmental Origins of Health and Disease...

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Literature Corpus work
f6642ac6-7ee8-5b32-ae65-1430adf521fa
DOI
10.1101/2020.11.25.398164
Open publication

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