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Article

p53/CEP-1 increases or decreases lifespan, depending on level of mitochondrial bioenergetic stress.

Aging cell - 1 Aug 2009

Ventura Natascia, Rea Shane L, Schiavi Alfonso, Torgovnick Alessandro, Testi Roberto, Johnson Thomas E

Abstract excerpt

Mitochondrial pathologies underlie a number of life-shortening diseases in humans. In the nematode Caenorhabditis elegans, severely reduced expression of mitochondrial proteins involved in electron transport chain-mediated energy production also leads to pathological phenotypes, including arrested development and/or shorter life; in sharp contrast, mild suppression of these same proteins extends lifespan. In this...

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Identifiers

PMID: 19416129
DOI: 10.1111/j.1474-9726.2009.00482.x
PMCID: PMC2730656

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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