Article

Cockayne syndrome proteins CSA and CSB maintain mitochondrial homeostasis through NAD <sup>+</sup> signaling

2020-03-02

Abstract excerpt

<h4>Background</h4> Cockayne syndrome (CS) is a rare premature aging disease, most commonly caused by mutations of the genes encoding the CSA or CSB proteins. CS patients display cachectic dwarfism and severe neurological manifestations and have an average life expectancy of 12 years. The CS proteins are involved in transcription and DNA repair, with the latter including transcription-coupled nucleotide excision...

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Literature Corpus work: 44467860-c83a-5dc8-a292-6ea8698ff6cd
DOI: 10.1101/2020.03.01.972323

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