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Article

The paradox of mitochondrial dysfunction and extended longevity.

Experimental gerontology - 1 Aug 2014

Munkácsy Erin, Rea Shane L

Abstract excerpt

Mitochondria play numerous, essential roles in the life of eukaryotes. Disruption of mitochondrial function in humans is often pathological or even lethal. Surprisingly, in some organisms mitochondrial dysfunction can result in life extension. This paradox has been studied most extensively in the long-lived Mit mutants of the nematode Caenorhabditis elegans. In this review, we explore the major responses that are...

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Identifiers

PMID: 24699406
DOI: 10.1016/j.exger.2014.03.016
PMCID: PMC4104296

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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