Article
Caenorhabditis elegans ATR checkpoint kinase ATL-1 influences life span through mitochondrial maintenance.
Mitochondrion - 1 Nov 2013
Suetomi Kazuhiro, Mereiter Stefan, Mori Chihiro, Takanami Takako, Higashitani Atsushi
Abstract excerpt
ATR is highly conserved in all eukaryotes and functions as a cell-cycle nuclear checkpoint kinase. In mammals, ATR is essential whose complete absence results in early embryonic lethality and its hypomorphic mutation causes a complex disease known as Seckel syndrome. However, molecular mechanisms that cause a wide variety of symptoms including accelerated aging have remained unclear. Similarly, in the nematode...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.