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Article

Maintenance of mitochondrial DNA by the Caenorhabditis elegans ATR checkpoint protein ATL-1.

Genetics - 1 Sept 2008

Mori Chihiro, Takanami Takako, Higashitani Atsushi

Abstract excerpt

Here we show that inactivation of the ATR-related kinase ATL-1 results in a significant reduction in mitochondrial DNA (mtDNA) copy numbers in Caenorhabditis elegans. Although ribonucleotide reductase (RNR) expression and the ATP/dATP ratio remained unaltered in atl-1 deletion mutants, inhibition of RNR by RNAi or hydroxyurea treatment caused further reductions in mtDNA copy number. These results suggest that...

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Identifiers

PMID: 18716329
DOI: 10.1534/genetics.108.090704
PMCID: PMC2535718

Genes

ATR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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