Article

Cross–Cell-Line Conservation-Resolved Interactions Reveal a Stepwise Cascade of CTCF Loop Formation

2026-02-24

Abstract excerpt

<title>Abstract</title> <p>The three-dimensional organization of the genome is shaped by CTCF-mediated chromatin loops, which vary widely in strength, conservation, and cell-type specificity. A longstanding model proposes that highly conserved loops form autonomously and establish a structural scaffold that supports the subsequent formation of less conserved, cell-type-specific interactions. However, genome-wide...

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Literature Corpus work: 521477b7-ae6a-5b83-b246-dbe3d8fd2de8
DOI: 10.21203/rs.3.rs-8752985/v1

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