Article

CLASH (Chromatin Loop Across-sample Score Harmonizer) quantifies the relative contributions of genetic variation, methylation, and CTCF occupancy on chromatin loop strength across individuals

2026-06-04

Abstract excerpt

Three-dimensional genome organization constrains the regulatory interactions that govern vital cellular processes. Chromatin loops are key features of genome folding, yet it is unclear how genetic and epigenetic variation influences differential loop formation across individuals. Loops primarily form between two CTCF binding proteins, which recognize a specific motif at loop anchors. CTCF binding site motifs are f...

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Literature Corpus work: 12b81716-74ad-591c-a10a-d16674c33e4d
DOI: 10.64898/2026.06.01.729143

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