Article

Microbiota-derived secondary bile acids promote STING activation and antitumor activity

2025-04-22

Abstract excerpt

Microbiota metabolism generates diverse bile acids that are associated with health and disease, but the molecular targets and mechanisms of action for these metabolites have not been fully elucidated. Using deoxycholic acid (DCA) photoaffinity probes, with cholic acid (CA) probe as a comparator, we found many protein targets of microbiota-derived DCA in mammalian cells. Of note, we discovered that DCA binds the tr...

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Literature Corpus work: 52090d96-275a-544c-9eb9-057fc2df000e
DOI: 10.1101/2025.04.16.649255

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