Article

Human gut bacteria produce T <sub>H</sub> 17-modulating bile acid metabolites

2021-01-09

Abstract excerpt

The microbiota plays a pivotal role in gut immune homeostasis. Bacteria influence the development and function of host immune cells, including T helper cells expressing interleukin-17a (T H 17 cells). We previously reported that the bile acid metabolite 3-oxolithocholic acid (3-oxoLCA) inhibits T H 17 cell differentiation 1 . While it was suggested that gut-residing bacteria produce 3-oxoLCA, the identity of su...

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Literature Corpus work: 0d9a6bb8-b73a-5c4c-bd61-f63f1eab9377
DOI: 10.1101/2021.01.08.425913

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