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Small-molecule perturbation profiling reveals a mechanistic link between STING signaling and lipid metabolism in macrophages and dendritic cells

2025-04-29

Abstract excerpt

The DNA sensor cGAS and the signaling adaptor STING play a key role in the innate immune response to microbial and endogenous DNA in the cytoplasm. The cGAS-STING signaling pathway has evolved to promote immune defense and organismal fitness, yet its dysregulation can lead to chronic inflammation, autoimmunity, and neurodegeneration. Upon sensing double- stranded DNA, cGAS produces a cyclic dinucleotide second mes...

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Identifiers and source

Literature Corpus work
6271eb84-532d-5ef2-a995-b9311637325b
DOI
10.1101/2025.04.25.650730
Open publication

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Small-molecule perturbation profiling reveals a mechanistic link between STING signaling and lipid metabolism in macrophages and dendritic cellsDOI 10.1101/2025.04.25.650730
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