Article

Microbially-conjugated Bile Salts Found in Human Bile Activate the Bile Salt Receptors TGR5 and FXR

2023-09-05

Abstract excerpt

<h4>Background & Aims</h4> Bile salts of hepatic and microbial origin mediate inter-organ crosstalk in the gut-liver axis. Here, we assessed whether the newly discovered class of microbial bile salt conjugates (MBSCs), activate the main host bile salt receptors (TGR5 and FXR) and enter the human systemic and enterohepatic circulation. <h4>Approach & Results</h4> N -amidates of (chenodeoxy)cholic acid and leucine...

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Literature Corpus work: 125a6820-d137-5fa7-9dfe-badced626f37
DOI: 10.1101/2023.09.04.556292

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