Article

A microbial derived bile acid acts as GPBAR1 agonist and RORγt inverse agonist and reverses inflammation in inflammatory bowel disease

2024-04-11

Abstract excerpt

The interplay between the dysbiotic microbiota and bile acids is a critical determinant for development of a dysregulated immune system in inflammatory bowel disease (IBD). Here we have investigated the fecal bile acid metabolome, gut microbiota composition, and immune responses in IBD patients and murine models of colitis and found that IBD associates with an elevated excretion of primary bile acids while seconda...

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Literature Corpus work: 3c6dd708-6d4a-53b8-ae7c-0812cf26698b
DOI: 10.1101/2024.04.08.588556

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