Article

Microbial Adaptation and Host Signaling: Bacteroides–Bile Acid Interactions in Gut Health

2025-08-26

Abstract excerpt

Bile acids are amphipathic molecules synthesized from cholesterol that act not only as digestive agents but also as key signaling molecules regulating host metabolic and immune pathways via FXR (farnesoid X receptor) and TGR5 (G protein-coupled bile acid receptor). In the colon, microbial metabolism profoundly transforms bile acids, modulating their composition, toxicity, and signaling potential. Among gut microbe...

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Literature Corpus work: 36589d99-8ade-5a0e-878f-531612939a92
DOI: 10.22541/au.175619764.45838175/v1

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