Article
A library of yeast transcription factor motifs reveals a widespread function for Rsc3 in targeting nucleosome exclusion at promoters.
Molecular cell - 26 Dec 2008
Badis Gwenael, Chan Esther T, van Bakel Harm, Pena-Castillo Lourdes, Tillo Desiree, Tsui Kyle, Carlson Clayton D, Gossett Andrea J, Hasinoff Michael J, Warren Christopher L, Gebbia Marinella, Talukder Shaheynoor, Yang Ally, Mnaimneh Sanie, Terterov Dimitri, Coburn David, Li Yeo Ai, Yeo Zhen Xuan, Clarke Neil D, Lieb Jason D, Ansari Aseem Z, Nislow Corey, Hughes Timothy R
Abstract excerpt
The sequence specificity of DNA-binding proteins is the primary mechanism by which the cell recognizes genomic features. Here, we describe systematic determination of yeast transcription factor DNA-binding specificities. We obtained binding specificities for 112 DNA-binding proteins representing 19 distinct structural classes. One-third of the binding specificities have not been previously reported. Several...
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