Article
Analysis of the association between transcription factor binding site variants and distinct accompanying regulatory motifs in yeast.
Gene - 10 Jan 2012
Chiang Sufeng, Swamy Krishna B S, Hsu Ting-Wei, Tsai Zing Tsung-Yeh, Lu Henry Horng-Shing, Wang Daryi, Tsai Huai-Kuang
Abstract excerpt
It is generally accepted that genes are regulated by the interactions between transcription factors (TFs) and their binding sites (TFBSs). Some studies have demonstrated that nucleotide variants at variable positions in TFBSs affect yeast gene regulation. Furthermore, variable positions in TFBSs in association with distinct accompanying regulatory motifs of other TFs (i.e., co-TFs) can also impact gene regulation...
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