Article

Identification of mammalian transcription factors that bind to inaccessible chromatin

2023-03-16

Abstract excerpt

Transcription factors (TFs) are proteins that affect gene expression by binding to regulatory regions of DNA in a sequence specific manner. The binding of TFs to DNA is controlled by many factors, including the DNA sequence, concentration of TF, chromatin accessibility and co-factors. Here, we systematically investigated the binding mechanism of hundreds of TFs by analysing ChIP-seq data with our explainable stati...

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Literature Corpus work: 80ac6202-9ef2-596a-8547-adc0fa06b790
DOI: 10.1101/2023.03.15.532796

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