Determination and inference of eukaryotic transcription factor sequence specificity.

doi:10.1016/j.cell.2014.08.009

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Article

Determination and inference of eukaryotic transcription factor sequence specificity.

Cell - 11 Sept 2014

Weirauch Matthew T, Yang Ally, Albu Mihai, Cote Atina G, Montenegro-Montero Alejandro, Drewe Philipp, Najafabadi Hamed S, Lambert Samuel A, Mann Ishminder, Cook Kate, Zheng Hong, Goity Alejandra, van Bakel Harm, Lozano Jean-Claude, Galli Mary, Lewsey Mathew G, Huang Eryong, Mukherjee Tuhin, Chen Xiaoting, Reece-Hoyes John S, Govindarajan Sridhar, Shaulsky Gad, Walhout Albertha J M, Bouget François-Yves, Ratsch Gunnar, Larrondo Luis F, Ecker Joseph R, Hughes Timothy R

Abstract excerpt

Transcription factor (TF) DNA sequence preferences direct their regulatory activity, but are currently known for only ∼1% of eukaryotic TFs. Broadly sampling DNA-binding domain (DBD) types from multiple eukaryotic clades, we determined DNA sequence preferences for >1,000 TFs encompassing 54 different DBD classes from 131 diverse eukaryotes. We find that closely related DBDs almost always have very similar DNA...

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Identifiers

PMID: 25215497
DOI: 10.1016/j.cell.2014.08.009
PMCID: PMC4163041

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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