Article

MYC modulates TOP2A diffusion to promote substrate detection and activity

2025-07-18

Abstract excerpt

Topoisomerases alleviate DNA supercoiling by cleaving and resealing DNA strands. Previously, we showed that the oncoprotein MYC recruits and stimulates topoisomerases to remove DNA entanglements generated by oncogenic transcription. Understanding this mechanism may suggest methods to inhibit MYC-driven topoisomerase activation, targeting tumor-specific transcription. Here, we demonstrate that the essential topoiso...

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Literature Corpus work: 343fc62a-5fdd-51dd-9934-725fe1984034
DOI: 10.1101/2025.07.15.665031

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