Article

Non-microglial downregulation of <i>PLCG2</i> impairs synaptic function and elicits Alzheimer disease-related hallmarks

2024-05-01

Abstract excerpt

<h4>ABSTRACT</h4> We developed a high content screening to investigate how Alzheimer disease (AD) genetic risk factors may affect synaptic mechanisms in rat primary neuronal cultures. Out of the target genes identified, we found that Plcg2 downregulation in mouse dentate gyrus neurons consistently disrupted dendritic morphology and synaptic function. In human neuronal cultures (hNCs), PLCG2 downregulation also...

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Literature Corpus work: 50c928ac-55e4-53fc-a90e-5eb90deb6c14
DOI: 10.1101/2024.04.29.591575

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