Article

Neuronal downregulation of PLCG2 impairs synaptic function and elicits Alzheimer disease hallmarks

2024-05-31

Abstract excerpt

<title>Abstract</title> <p>We developed a high content screening to investigate how Alzheimer disease (AD) genetic risk factors may impair synaptic mechanisms in rat primary neuronal cultures. Out of the gene targets identified, we found that shRNA-mediated downregulation of Plcg2 in mouse dentate gyrus neurons consistently impaired dendritic morphology and synaptic function. In human neuronal cultures (hNCs), PL...

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Literature Corpus work: 3fc53dce-4607-5f86-94e5-8683c22b5a8a
DOI: 10.21203/rs.3.rs-4437808/v1

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