Article

Genetics of PLCG2 expression and splicing relative to Alzheimer’s disease risk

2025-06-19

Abstract excerpt

<title>Abstract</title> <p>Background PLCG2 is associated with the risk of Alzheimer’s disease (AD) through a rare missense polymorphism, rs72824905 (P522R) as well as a common variant, rs12445675, within a long non-coding RNA adjacent to <italic>PLCG2</italic>. Elucidating the impact of genetics on PLCG2 expression and splicing will provide insights into the role of PLCG2 in AD risk and, potentially, treatments...

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Literature Corpus work: 094e9ae3-3440-5aab-9327-dc6945367c4a
DOI: 10.21203/rs.3.rs-6735123/v1

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