Article

Identification of a specific APOE transcript and functional elements associated with Alzheimer’s disease

2023-10-31

Abstract excerpt

<h4>ABSTRACT</h4> <h4>INTRODUCTION</h4> The APOE gene is the strongest genetic risk factor for late-onset Alzheimer’s Disease (LOAD). However, the gene regulatory mechanisms at this locus have not been fully characterized. <h4>METHODS</h4> To identify novel AD-linked functional elements within the APOE locus, we integrated SNP variants with RNA-seq, DNA methylation, and ChIP-seq data from human postmortem brains....

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Literature Corpus work: 50c4a0e3-69dd-58d4-8d29-72ca21c3f378
DOI: 10.1101/2023.10.30.23297431

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