Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Understanding Alzheimer Disease at the Interface between Genetics and Transcriptomics.

Trends in genetics : TIG - 1 Jun 2018

Verheijen Jan, Sleegers Kristel

Abstract excerpt

Over 25 genes are known to affect the risk of developing Alzheimer disease (AD), the most common neurodegenerative dementia. However, mechanistic insights and improved disease management remains limited, due to difficulties in determining the functional consequences of genetic associations. Transcriptomics is increasingly being used to corroborate or enhance interpretation of genetic discoveries. These...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease
Share to Brain
Share to Brain Mapping

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Computational Biology

Share to Gene Expression

Share to Metabolic Networks and Pathways

Share to Single-Cell Analysis

Share to Transcriptome

Source

Identifiers

PMID: 29573818
DOI: 10.1016/j.tig.2018.02.007

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Understanding Alzheimer Disease at the Interface between Genetics and Transcriptomics.PMID 29573818Read ↗

Alzheimer's disease genetics: from the bench to the clinic.Semantic proximity Read ↗

Single-cell transcriptomic analysis reveals APOE genotype-dependent sex differences in Alzheimer's disease.Semantic proximity Read ↗

Beyond association: successes and challenges in linking non-coding genetic variation to functional consequences that modulate Alzheimer's disease risk.Semantic proximity Read ↗

The Landscape of Sex- and APOE Genotype-Specific Transcriptional Changes in Alzheimer’s Disease at the Single Cell LevelSemantic proximity Read ↗

Genomics and Functional Genomics of Alzheimer's Disease.Semantic proximity Read ↗

Brain Region-Dependent Alternative Splicing of Alzheimer Disease (AD)-Risk Genes Is Associated With Neuropathological Features in ADSemantic proximity Read ↗

Transcriptomics in Alzheimer’s Disease: Aspects and ChallengesSemantic proximity Read ↗

The broken Alzheimer’s disease genomeSemantic proximity Read ↗

Genomic variants, genes, and pathways of Alzheimer's disease: An overview.Semantic proximity Read ↗

Cell-type-aware transcriptome-wide association studies identify 91 independent risk genes for Alzheimer's disease dementia.Semantic proximity Read ↗

Genome-wide analysis furthers decoding of Alzheimer disease genetics.Semantic proximity Read ↗

Advances in Genetics and Epigenetic Alterations in Alzheimer's Disease: A Notion for Therapeutic Treatment.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.