Article

Inferring the molecular mechanisms of noncoding Alzheimer’s disease-associated genetic variants

2018-08-27

Abstract excerpt

<h4>Structured Abstract</h4> <h4>INTRODUCTION</h4> We set out to characterize the causal variants, regulatory mechanisms, tissue contexts, and target genes underlying noncoding late-onset Alzheimer’s Disease (LOAD)-associated genetic signals. <h4>METHODS</h4> We applied our INFERNO method to the IGAP genome-wide association study (GWAS) data, annotating all potentially causal variants with tissue-specific regul...

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Literature Corpus work: e5d69a5f-7443-5787-ab4b-3d0d92c92a7c
DOI: 10.1101/401471

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