Article
Identification of a specific APOE transcript and functional elements associated with Alzheimer's disease.
Molecular neurodegeneration - 29 Aug 2024
Chen Qiang, Aguirre Luis, Liang Guoming, Zhao Huanhuan, Dong Tao, Borrego Felix, de Rojas Itziar, Hu Qichan, Reyes Christopher, Su Ling-Yan, Zhang Bao, Lechleiter James D, Göring Harald H H, De Jager Philip L, Kleinman Joel E, Hyde Thomas M, Li Pan P, Ruiz Agustín, Weinberger Daniel R, Seshadri Sudha, Ma Liang
Abstract excerpt
BACKGROUND: The APOE gene is the strongest genetic risk factor for late-onset Alzheimer's Disease (LOAD). However, the gene regulatory mechanisms at this locus remain incompletely characterized. METHODS: To identify novel AD-linked functional elements within the APOE locus, we integrated SNP variants with multi-omics data from human postmortem brains including 2,179 RNA-seq samples from 3 brain regions and two...
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