Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Distinct Regulatory Genomic Architectures Distinguish Early-Onset from Late-Onset Alzheimer's Disease.

Genes - 31 Jan 2026

Roa-Bruzón Iliannis Yisel, Gazcón-Rivas Celeste Patricia, Garibaldi-Ríos Asbiel Felipe, Duany-Almira Luis Félix, Gallegos-Arreola Martha Patricia, Palafox-Sánchez Claudia Azucena, Ortuño-Sahagún Daniel, Figuera Luis Eduardo, Rico-Méndez Manuel Alejandro, Valle Yeminia

Abstract excerpt

Background/Objectives: Alzheimer's disease (AD) exhibits marked genetic heterogeneity between early-onset (EOAD) and late-onset (LOAD) forms. EOAD is typically associated with highly penetrant variants, whereas LOAD follows a polygenic architecture dominated by non-coding variation. However, the tissue-specific regulatory consequences of these variants remain insufficiently characterized. This study aimed to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age of Onset
Share to Alzheimer Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to APOE gene

Share to Genetic Predisposition to Disease

Share to Genome-Wide Association Study

Share to Genomics

Share to Polymorphism, Single Nucleotide

Share to Quantitative Trait Loci

Source

Open in PubMed Open full text

Identifiers

PMID: 41751570
DOI: 10.3390/genes17020186
PMCID: PMC12940409

Genes

GSE1
APH1B
APOE
CEP63
HAVCR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Distinct Regulatory Genomic Architectures Distinguish Early-Onset from Late-Onset Alzheimer's Disease.PMID 41751570Read ↗

Understanding Alzheimer Disease at the Interface between Genetics and Transcriptomics.Semantic proximity Read ↗

Late-onset Alzheimer disease risk variants mark brain regulatory lociSemantic proximity Read ↗

Inferring the molecular mechanisms of noncoding Alzheimer’s disease-associated genetic variantsSemantic proximity Read ↗

Genomic variants, genes, and pathways of Alzheimer's disease: An overview.Semantic proximity Read ↗

Dissecting Complex and Multifactorial Nature of Alzheimer's Disease Pathogenesis: a Clinical, Genomic, and Systems Biology Perspective.Semantic proximity Read ↗

Brain Region-Dependent Alternative Splicing of Alzheimer Disease (AD)-Risk Genes Is Associated With Neuropathological Features in ADSemantic proximity Read ↗

Analysis of Alzheimer’s disease Polygenic Risk Scores using RNA-sequencing provides further novel biological pathwaysSemantic proximity Read ↗

Genetically regulated expression in late-onset Alzheimer's disease implicates risk genes within known and novel loci.Semantic proximity Read ↗

Silencer variants are key drivers of gene upregulation in Alzheimer’s diseaseSemantic proximity Read ↗

Predicting brain-regional gene regulatory networks from multi-omics for Alzheimer's disease phenotypes and Covid-19 severity.Semantic proximity Read ↗

Whole exome sequencing study identifies novel rare and common Alzheimer’s-Associated variants involved in immune response and transcriptional regulationSemantic proximity Read ↗

Exploring the role of common regulatory variants in the etiology of late-onset Alzheimer’s diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.