Article

Mutations to the HCoV-229E spike have counterbalancing effects on serum antibody neutralization and receptor binding

2026-02-23

Abstract excerpt

Human coronavirus 229E (HCoV-229E) is an endemic pathogen that causes repeated "common-cold" infections throughout life. Like other coronaviruses, it accumulates spike mutations that erode antibody immunity and enable reinfection. Here, we use pseudovirus deep mutational scanning to measure how mutations to the HCoV-229E spike affect its cell entry function, binding to its human APN receptor, and neutralization by...

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Literature Corpus work: 4f8cbdec-a612-5466-b133-47e6add454ff
DOI: 10.64898/2026.02.22.707297

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