Article

Full-spike deep mutational scanning helps predict the evolutionary success of SARS-CoV-2 clades

2023-11-14

Abstract excerpt

SARS-CoV-2 variants acquire mutations in spike that promote immune evasion and impact other properties that contribute to viral fitness such as ACE2 receptor binding and cell entry. Knowledge of how mutations affect these spike phenotypes can provide insight into the current and potential future evolution of the virus. Here we use pseudovirus deep mutational scanning to measure how >9,000 mutations across the full...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 865ae7d1-6c5b-512d-8958-20a60f84533b
DOI: 10.1101/2023.11.13.566961

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Full-spike deep mutational scanning helps predict the evolutionary success of SARS-CoV-2 cladesDOI 10.1101/2023.11.13.566961Read

Spike deep mutational scanning helps predict success of SARS-CoV-2 clades.Semantic proximity Read

Spike mutations that affect the function and antigenicity of recent KP.3.1.1-like SARS-CoV-2 variantsSemantic proximity Read

Spike mutations that affect the function and antigenicity of recent KP.3.1.1-like SARS-CoV-2 variants.Semantic proximity Read

Deep mutational scanning of whole SARS-CoV-2 spike in an inverted infection systemSemantic proximity Read

Functional and structural characterization of the SARS-CoV-2 spike N481K mutation.Semantic proximity Read

Mutations in the SARS-CoV-2 spike receptor binding domain and their delicate balance between ACE2 affinity and antibody evasionSemantic proximity Read

Deep mutational scanning of SARS-CoV-2 Omicron BA.2.86 and epistatic emergence of the KP.3 variantSemantic proximity Read

Signatures in SARS-CoV-2 spike protein conferring escape to neutralizing antibodies.Semantic proximity Read

Deep mutational scanning of SARS-CoV-2 Omicron BA.2.86 and epistatic emergence of the KP.3 variantSemantic proximity Read

Amino acids 484 and 494 of SARS-CoV-2 spike are hotspots of immune evasion affecting antibody but not ACE2 bindingSemantic proximity Read

A pseudovirus system enables deep mutational scanning of the full SARS-CoV-2 spike.Semantic proximity Read

Deep mutational scans of XBB.1.5 and BQ.1.1 reveal ongoing epistatic drift during SARS-CoV-2 evolution.Semantic proximity Read