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Article

Functional and structural characterization of the SARS-CoV-2 spike N481K mutation.

Archives of virology - 4 Jun 2026

Smatti Maria K, Al-Khatib Hebah, Suleman Muhammad, Nizar Muna, Khalid Hala Abo, Ismail Ruaa, Nasrallah Gheyath K, Yassine Hadi M

Abstract excerpt

BACKGROUND: Selective pressure drives SARS-CoV-2 evolution, with spike RBD substitutions shaping ACE2 binding and antibody escape. N481K RBD mutation emerged early in Qatar (2020) and later re-emerged globally, reaching near-fixation by 2024-2025, yet its functional significance remained unexplored. METHODS: We analyzed the temporal and geographic circulation of N481K across > 17 million SARS-CoV-2 genomes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42243594
DOI: 10.1007/s00705-026-06652-y
PMCID: PMC13236748

Genes

ACE2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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