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Defining neutralization and allostery by antibodies against COVID-19 variants

1 Nov 2023

Abstract excerpt

The changing landscape of SARS-CoV-2 Spike protein is linked to the emergence of variants, immune-escape and reduced efficacy of the existing repertoire of anti-viral antibodies. The functional activity of neutralizing antibodies is linked to their quaternary changes occurring as a result of antibody-Spike trimer interactions. Here, we reveal the conformational dynamics and allosteric perturbations linked to...

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PMID: 37907459
DOI: 10.1038/s41467-023-42408-x

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