Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Spike deep mutational scanning helps predict success of SARS-CoV-2 clades.

Nature - 1 Jul 2024

Dadonaite Bernadeta, Brown Jack, McMahon Teagan E, Farrell Ariana G, Figgins Marlin D, Asarnow Daniel, Stewart Cameron, Lee Jimin, Logue Jenni, Bedford Trevor, Murrell Ben, Chu Helen Y, Veesler David, Bloom Jesse D

Abstract excerpt

SARS-CoV-2 variants acquire mutations in the spike protein that promote immune evasion1 and affect other properties that contribute to viral fitness, such as ACE2 receptor binding and cell entry2,3. Knowledge of how mutations affect these spike phenotypes can provide insight into the current and potential future evolution of the virus. Here we use pseudovirus deep mutational scanning4 to measure how more than...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Angiotensin-Converting Enzyme 2
Share to Antibodies, Neutralizing

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Antibodies, Viral

Share to Genetic Fitness

Share to Immune Evasion

Share to Neutralization Tests

Share to Spike Glycoprotein, Coronavirus

Share to Virus Internalization

Source

Open in PubMed Open full text

Identifiers

PMID: 38961298
DOI: 10.1038/s41586-024-07636-1
PMCID: PMC11254757

Genes

ACE2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Spike deep mutational scanning helps predict success of SARS-CoV-2 clades.PMID 38961298Read ↗

Full-spike deep mutational scanning helps predict the evolutionary success of SARS-CoV-2 cladesSemantic proximity Read ↗

Spike mutations that affect the function and antigenicity of recent KP.3.1.1-like SARS-CoV-2 variantsSemantic proximity Read ↗

Spike mutations that affect the function and antigenicity of recent KP.3.1.1-like SARS-CoV-2 variants.Semantic proximity Read ↗

Deep mutational scanning of whole SARS-CoV-2 spike in an inverted infection systemSemantic proximity Read ↗

A pseudovirus system enables deep mutational scanning of the full SARS-CoV-2 spike.Semantic proximity Read ↗

Functional and structural characterization of the SARS-CoV-2 spike N481K mutation.Semantic proximity Read ↗

Signatures in SARS-CoV-2 spike protein conferring escape to neutralizing antibodies.Semantic proximity Read ↗

Mutations in the SARS-CoV-2 spike receptor binding domain and their delicate balance between ACE2 affinity and antibody evasionSemantic proximity Read ↗

Perspectives: SARS-CoV-2 Spike Convergent Evolution as a Guide to Explore Adaptive Advantage.Semantic proximity Read ↗

Deep mutational scanning of SARS-CoV-2 Omicron BA.2.86 and epistatic emergence of the KP.3 variantSemantic proximity Read ↗

Epistasis and background dependence in the evolution of Omicron variants of the SARS-CoV-2 Spike proteinSemantic proximity Read ↗

Mutations and Evolution of the SARS-CoV-2 Spike Protein.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.