Article

Deep mutational scanning of whole SARS-CoV-2 spike in an inverted infection system

2023-07-18

Abstract excerpt

<h4>Summary</h4> In order to investigate SARS-CoV-2 mutations and their impact on immune evasion and infectivity, we developed a Deep Mutational Scanning (DMS) platform utilizing an inverted infection assay to measure spike expression, ACE2 affinity, and viral infectivity in human cells. Surprisingly, our analysis reveals that spike protein expression, rather than ACE2 affinity, is the primary factor affecting vi...

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Literature Corpus work: efe971c7-84f4-5d98-9bfc-a74ee39799c4
DOI: 10.1101/2023.07.17.549430

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