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Article

Spike mutations that affect the function and antigenicity of recent KP.3.1.1-like SARS-CoV-2 variants.

Journal of virology - 25 Nov 2025

Dadonaite Bernadeta, Harari Sheri, Larsen Brendan B, Kampman Lucas, Harteloo Alex, Elias-Warren Anna, Chu Helen Y, Bloom Jesse D

Abstract excerpt

SARS-CoV-2 is under strong evolutionary selection to acquire mutations in its spike protein that reduce neutralization by human polyclonal antibodies. Here, we use pseudovirus-based deep mutational scanning to measure how mutations to the spike from the recent KP.3.1.1 SARS-CoV-2 strain affect cell entry, binding to the ACE2 receptor, RBD up/down motion, and neutralization by human sera and clinically relevant...

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Share to Angiotensin-Converting Enzyme 2
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41081510
DOI: 10.1128/jvi.01423-25
PMCID: PMC12614646

Genes

ACE2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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