Article

Spike mutations that affect the function and antigenicity of recent KP.3.1.1-like SARS-CoV-2 variants

2025-08-19

Abstract excerpt

SARS-CoV-2 is under strong evolutionary selection to acquire mutations in its spike protein that reduce neutralization by human polyclonal antibodies. Here we use pseudovirus-based deep mutational scanning to measure how mutations to the spike from the recent KP.3.1.1 SARS-CoV-2 strain affect cell entry, binding to ACE2 receptor, RBD up/down motion, and neutralization by human sera and clinically relevant antibodi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a809ab68-6675-58d7-b914-5ccb22275860
DOI: 10.1101/2025.08.18.671001

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Spike mutations that affect the function and antigenicity of recent KP.3.1.1-like SARS-CoV-2 variantsDOI 10.1101/2025.08.18.671001Read

Spike mutations that affect the function and antigenicity of recent KP.3.1.1-like SARS-CoV-2 variants.Semantic proximity Read

Full-spike deep mutational scanning helps predict the evolutionary success of SARS-CoV-2 cladesSemantic proximity Read

Spike deep mutational scanning helps predict success of SARS-CoV-2 clades.Semantic proximity Read

Mutations and Evolution of the SARS-CoV-2 Spike Protein.Semantic proximity Read

Functional and structural characterization of the SARS-CoV-2 spike N481K mutation.Semantic proximity Read

The impact of Spike mutations on SARS-CoV-2 neutralizationSemantic proximity Read

Large-scale population analysis of SARS-CoV-2 whole genome sequences reveals host-mediated viral evolution with emergence of mutations in the viral Spike protein associated with elevated mortality ratesSemantic proximity Read

A High-Resolution Approach to Mapping Spike Protein Evolution for Advancing Antibody Therapy DesignSemantic proximity Read

Spike mutation pipeline reveals the emergence of a more transmissible form of SARS-CoV-2Semantic proximity Read

Amino acids 484 and 494 of SARS-CoV-2 spike are hotspots of immune evasion affecting antibody but not ACE2 bindingSemantic proximity Read

Epidemiology and Characteristics of SARS-CoV-2 Variants of Concern: The Impacts of the Spike MutationsSemantic proximity Read

Perspectives: SARS-CoV-2 Spike Convergent Evolution as a Guide to Explore Adaptive Advantage.Semantic proximity Read