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Article

Structural Modeling of the SARS-CoV-2 Spike/Human ACE2 Complex Interface can Identify High-Affinity Variants Associated with Increased Transmissibility.

Journal of molecular biology - 23 Jul 2021

Gan Hin Hark, Twaddle Alan, Marchand Benoit, Gunsalus Kristin C

Abstract excerpt

The COVID-19 pandemic has triggered concerns about the emergence of more infectious and pathogenic viral strains. As a public health measure, efficient screening methods are needed to determine the functional effects of new sequence variants. Here we show that structural modeling of SARS-CoV-2 Spike protein binding to the human ACE2 receptor, the first step in host-cell entry, predicts many novel variant...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33992693
DOI: 10.1016/j.jmb.2021.167051
PMCID: PMC8118711

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