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Bcl-2 protein Noxa is required for metabolic reprogramming to glutamine dependence and for apoptosis in stimulated human CD8 <sup>+</sup> T cells

2025-12-10

Abstract excerpt

<h4>ABSTRACT</h4> Naïve or memory T cells reprogram their metabolism upon antigenic stimulation. They increase their glucose uptake, relying on aerobic glycolysis for generating biomass while switching to glutamine to fuel energy production. Here we have identified a requirement for human Bcl-2 family, Noxa, in the metabolic switch to glutamine dependence in activated CD8 + T cells, that is independent of its ca...

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Literature Corpus work
10d0f4c7-adc1-588d-8f1a-434cf7b7cdd6
DOI
10.64898/2025.12.08.692849
Open publication

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Bcl-2 protein Noxa is required for metabolic reprogramming to glutamine dependence and for apoptosis in stimulated human CD8 <sup>+</sup> T cellsDOI 10.64898/2025.12.08.692849
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