Amino Acid Metabolism in Lupus.

doi:10.3389/fimmu.2021.623844

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Article

Amino Acid Metabolism in Lupus.

Frontiers in immunology - 1 Jan 2021

Kono Michihito, Yoshida Nobuya, Tsokos George C

Abstract excerpt

T cell metabolism is central to cell proliferation, survival, differentiation, and aberrations have been linked to the pathophysiology of systemic autoimmune diseases. Besides glycolysis and fatty acid oxidation/synthesis, amino acid metabolism is also crucial in T cell metabolism. It appears that each T cell subset favors a unique metabolic process and that metabolic reprogramming changes cell fate. Here, we...

Topics

Amino Acid Transport Systems
Amino Acids
Animals
Autoimmunity
Energy Metabolism
Humans
Lupus Erythematosus, Systemic
Lymphocyte Activation
Phenotype
T-Lymphocytes

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Identifiers

PMID: 33692797
DOI: 10.3389/fimmu.2021.623844
PMCID: PMC7938307

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