Metabolic pathways in T cell activation and lineage differentiation.

doi:10.1016/j.smim.2016.10.009

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Article

Metabolic pathways in T cell activation and lineage differentiation.

Seminars in immunology - 1 Oct 2016

Almeida Luís, Lochner Matthias, Berod Luciana, Sparwasser Tim

Abstract excerpt

Recent advances in the field of immunometabolism support the concept that fundamental processes in T cell biology, such as TCR-mediated activation and T helper lineage differentiation, are closely linked to changes in the cellular metabolic programs. Although the major task of the intermediate metabolism is to provide the cell with a constant supply of energy and molecular precursors for the production of...

Topics

Animals
Cell Differentiation
Energy Metabolism
Fatty Acids
Glycolysis
Humans
Immunologic Memory
Lymphocyte Activation
Metabolic Networks and Pathways
Mitochondria
Phenotype
Signal Transduction
T-Lymphocyte Subsets

Source

Open in PubMed

Identifiers

PMID: 27825556
DOI: 10.1016/j.smim.2016.10.009

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