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Article

α-ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming.

Nature immunology - 1 Sept 2017

Liu Pu-Ste, Wang Haiping, Li Xiaoyun, Chao Tung, Teav Tony, Christen Stefan, Di Conza Giusy, Cheng Wan-Chen, Chou Chih-Hung, Vavakova Magdalena, Muret Charlotte, Debackere Koen, Mazzone Massimiliano, Huang Hsien-Da, Fendt Sarah-Maria, Ivanisevic Julijana, Ho Ping-Chih

Abstract excerpt

Glutamine metabolism provides synergistic support for macrophage activation and elicitation of desirable immune responses; however, the underlying mechanisms regulated by glutamine metabolism to orchestrate macrophage activation remain unclear. Here we show that the production of α-ketoglutarate (αKG) via glutaminolysis is important for alternative (M2) activation of macrophages, including engagement of fatty...

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Identifiers

PMID: 28714978
DOI: 10.1038/ni.3796

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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