Article

γ-aminobutyrate (GAB) functions as a bioenergetic and signaling gatekeeper to control T cell inflammation

2022-02-19

Abstract excerpt

γ-Aminobutyrate (GAB) is the biochemical form of γ-aminobutyric acid (GABA) at physiological pH and functions as an essential neurotransmitter in the vertebrate’s central nervous system (CNS). Growing evidence suggests that GAB may also mediate intercellular communications to shape various physiological processes, including immune response. Beyond acting as a paracrine signaling molecule, how GAB metabolism is con...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 95c7f42a-27e9-5b95-8232-9a231b199d8b
DOI: 10.1101/2022.02.17.480926

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

γ-aminobutyrate (GAB) functions as a bioenergetic and signaling gatekeeper to control T cell inflammationDOI 10.1101/2022.02.17.480926Read

Cellular metabolism regulates the differentiation and function of T-cell subsetsSemantic proximity Read

Metabolic T-cell phenotypes: from bioenergetics to function.Semantic proximity Read

Synthetic auxotrophy reveals metabolic regulation of plasma cell generation, affinity maturation, and cytokine receptor signalingSemantic proximity Read

Metabolic control of T cells in autoimmunitySemantic proximity Read

Metabolic imbalance driving immune cell phenotype switching in autoimmune disorders: Tipping the balance of T- and B-cell interactions.Semantic proximity Read

Metabolic Program of Regulatory B Lymphocytes and Influence in the Control of Malignant and Autoimmune Situations.Semantic proximity Read

Metabolic and Epigenomic Regulation of Th17/Treg Balance by the Polyamine PathwaySemantic proximity Read

NKT cells adopt a glutamine-addicted phenotype to regulate their homeostasis and function.Semantic proximity Read

Super-dosed butyrate induces a revisable metabolic paralysis through transient mitochondrial reprogramming in the gut-brain axisSemantic proximity Read

Metabolic pathways in T cell activation and lineage differentiation.Semantic proximity Read

Amino Acid Metabolism in Lupus.Semantic proximity Read

Which Role Plays 2-Hydroxybutyric Acid on Insulin Resistance?Semantic proximity Read