Article

A cell-based probabilistic approach unveils the concerted action of miRNAs

2018-04-10

Abstract excerpt

<h4>Summary</h4> Mature microRNAs (miRNAs) regulate most human genes through direct base-pairing with mRNAs. We investigate some underlying principles of such regulation. To this end, we overexpressed miRNAs in different cell types and measured the mRNA decay rate under transcriptional arrest. Parameters extracted from these experiments were incorporated into a computational stochastic framework which was develop...

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Literature Corpus work: 4f56054a-717d-5ef7-80d2-5851a4c3dde1
DOI: 10.1101/298596

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