Article

Decoupled degradation and translation enables noise-modulation by poly(A)-tails

2024-02-26

Abstract excerpt

<h4>SUMMARY</h4> Poly(A)-tails are crucial for mRNA translation and degradation, but the exact relationship between tail length and mRNA kinetics remains unclear. Here we employ a small library of identical mRNAs that differ only in their poly(A)-tail length to examine their behavior in human embryonic kidney cells. We find that tail length strongly correlates with mRNA degradation rates, but is decoupled from tr...

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Literature Corpus work: 23bac0a7-9b0e-5e50-9f8e-4fb45ae97217
DOI: 10.1101/2024.02.26.582038

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