Article

Joint distribution of nuclear and cytoplasmic mRNA levels in stochastic models of gene expression: analytical results and parameter inference

2024-04-30

Abstract excerpt

Common stochastic models of gene expression predict the analytical distribution of the total mRNA level per cell but not at subcellular resolution. Here, for a wide class of models of transcription initiation, we obtain an exact steady-state solution for the joint distribution of nuclear and cytoplasmic mRNA levels per cell. Correcting the solution for extrinsic noise and fitting to single human cell data, we prec...

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Identifiers and source

Literature Corpus work: 8668a389-07a8-5dd9-9975-bcbf150ee878
DOI: 10.1101/2024.04.29.591679

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