Article
MiRNA-Target Interaction Reveals Cell-Specific Post-Transcriptional Regulation in Mammalian Cell Lines.
International journal of molecular sciences - 8 Jan 2016
Kulkarni Varun, Naqvi Afsar Raza, Uttamani Juhi Raju, Nares Salvador
Abstract excerpt
MicroRNAs are 18-22 nucleotides long, non-coding RNAs that bind transcripts with complementary sequences leading to either mRNA degradation or translational suppression. However, the inherent differences in preferred mode of miRNA regulation among cells of different origin have not been examined. In our previous transcriptome profiling studies, we observed that post-transcriptional regulation can differ...
Topics
- Animals
- COS Cells
- Cell Line
- Chlorocebus aethiops
- Gene Expression Regulation
- Genes, Reporter
- HeLa Cells
- Hep G2 Cells
- Human Umbilical Vein Endothelial Cells
- Humans
- Mice
- MicroRNAs
- Mutation
- NIH 3T3 Cells
- Protein Biosynthesis