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Article

On the role of extrinsic noise in microRNA-mediated bimodal gene expression.

PLoS computational biology - 1 Apr 2018

Del Giudice Marco, Bo Stefano, Grigolon Silvia, Bosia Carla

Abstract excerpt

Several studies highlighted the relevance of extrinsic noise in shaping cell decision making and differentiation in molecular networks. Bimodal distributions of gene expression levels provide experimental evidence of phenotypic differentiation, where the modes of the distribution often correspond to different physiological states of the system. We theoretically address the presence of bimodal phenotypes in the...

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Identifiers

PMID: 29664903
DOI: 10.1371/journal.pcbi.1006063
PMCID: PMC5922620

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